Unveiling the impact of topical formulations on the organisation of skin lipid barrier
X-ray diffraction reveals the structural organisation of the intercorneocyte lipids in the stratum corneum X-ray microdiffraction (µXRD) unveils the structural…
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X-ray microdiffraction (µXRD) unveils the structural organization of the intercorneocyte lipids in the stratum corneum :
Protocol
Information obtained
The cream disrupts the molecular architecture of inter-cellular lipids in the outer side while those in the epidermal side are not modified.
The impact of topical formulations on the lipid barrier of the stratum corneum is frequently studied for cosmetic purposes using µ-XRD. This technique is now gaining traction in the pharmaceutical field, offering novel and valuable insights that can significantly benefit R&D and formulation.
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